Large Breast Issue
The biggest issue with creating realistic large breasts is the side breast limitation. If we take Kate Upton for example, her breasts look real because the side boob folds over and extends under the armpit. For all the morphs created for breast shaping this is the most critical one that is missing imo. If there was an option to play with the mass/hight/width of the side boob the world would be a wonderful place!
Comments
You can pose each individual pectoral in parameters or rotate tool if using Genesis 2 or 3.
If you have the Daz Female morphs you can play with the Breast Heavy dial or Natural Breast dial as well as multiple breast shapes that look natural.
There is also zev0's breast control which is available for each genesis models that comes wtih similar Breast Sag dial, a bunch of Breast Curve , Under Curve and Armpit Curve dials as well as more pose control dials in parameters that let you rotate, change width, flatten and move breast together or apart.
Last but more complicated is using Dformers to morph the breast manually to your liking or even more complicated create your own morph through seperate 3d software.